Q: How It Works

Transmission Raman The TRS100 is a non-destructive, bulk analytical technique used in pharmaceutical R&D and QC manufacturing—for both qualitative and quantitative testing, such as content uniformity analysis. The fast scan time and automated tray system allows hundreds of samples to be analyzed in a single session. A range of standard and custom trays for tablets, capsules, liquids, and powders is available. The TRS100 software is compliant to 21 CFR part 11, and relevant USP and EP chapters. Non-destructive bulk analysis The TRS100 obtains a measurement by directing the laser through the sample from the underside. The resulting Raman spectrum comes from the bulk of the sample and is therefore representative of the entire sample. The TRS100 uses an 830 nm laser, specifically chosen for pharmaceutical samples as a balance between signal levels, and competing fluorescence of common pharmaceutical excipients. Calculate your content uniformity ROI Use our value calculator to see for yourself how much and how soon you could save compared to your current workflows. The typical example, where 3 batches are analyzed per day, delivers ~$450K of savings in less than 3 years. TRS100 benefits from no sample preparation, no solvents, lower cost of analysis, and lower cost of ownership. Higher volume products and more laborious workflows pay back even faster! Environmental impact The TRS100 has been independently audited for its environmental impact and has received the ACT (Accountability, Consistency, Transparency) label, published by My Green Lab. See how you can reduce your lab’s environmental impact with sustainability-driven innovation.

Q: Applications

Content uniformity testing The TRS100 is used for assay and content uniformity (CU) analysis. This fast, non-destructive technique, requiring no sample preparation, can generate a quantitative CU result in less than 15 minutes. The TRS100 has been approved by regulators and is used to create cost-effective analytical workflows. Watch our customer webinars and learn how pharmaceutical companies are streamlining their QC analytical workflows. Polymorphs The TRS100 can be used for polymorph and crystallinity analysis of powders and whole intact tablets for both qualitative and quantitative analysis. The TRS100 can detect residual crystallinity with a limit of detection (LOD) of 0.1-1% w/w. The ability to ‘see’ inside your pharmaceutical product non-destructively and measure the same sample repeatedly has useful applications in formulation development and stability studies. Sample versatility The TRS100 can be used to analyze a variety of sample types including—tablets, hard and soft gel capsules, powders, vials, cuvettes, and well plates. The versatility of sample presentation options enables a breadth of potential applications, which can all benefit from bulk high-throughput screening.

Q: Technology

Transmission Raman Spectroscopy (TRS) Transmission Raman Spectroscopy (TRS) is an ideal method for quantitative analysis of mixtures such as tablets capsules, powders, liquids and suspensions.

Question 1

Features

Accepted Answer

Assay hundreds of tablets or capsules in minutes.
Works with intact capsules and coated tablets of most thicknesses.
Requires no sample preparation, wet chemistry, or skilled testing resources.
Quantifies APIs and excipients in a single measurement.
Achieves a limit of quantification as low as 0.1% w/w.
Quantifies polymorphs in intact tablets.
Lean calibration models—easy to build and maintain.
Methods approved by regulators.
A range of sample trays and accessories for tablets, capsules, liquids, and powders are available.
Built-in technical controls ensure the security of your data, control access, and facilitate compliance as defined by US FDA 21 CFR Part 11 and EU Annex 11 regulations.
Choose sustainability: The Cary 60 UV-Vis received My Green Lab’s ACT (Accountability, Consistency, Transparency) label after independent audit for its environmental impact throughout the product lifecycle.

Question 2

Specifications

Accepted Answer

Calibration Standards NIST SRM706a polystyrene NIST SRM2246 green glass Calibration tray with mercury argon light source Compliance 21 CFR Part 11 USP <858> USP<1858> EP <2.2.48> Laser Power 650 mW Laser Wavelength(s) 830 nm Resolution < 8 cm-1 (FWHM) Sample Tray Types (Optional) Tablets Capsules Powders Vials Well plates Spectral Range 50 to 2,300 cm-1

Question 3

How It Works

Accepted Answer

Transmission Raman
The TRS100 is a non-destructive, bulk analytical technique used in pharmaceutical R&D and QC manufacturing—for both qualitative and quantitative testing, such as content uniformity analysis. The fast scan time and automated tray system allows hundreds of samples to be analyzed in a single session. A range of standard and custom trays for tablets, capsules, liquids, and powders is available.
The TRS100 software is compliant to 21 CFR part 11, and relevant USP and EP chapters.
Non-destructive bulk analysis
The TRS100 obtains a measurement by directing the laser through the sample from the underside. The resulting Raman spectrum comes from the bulk of the sample and is therefore representative of the entire sample.
The TRS100 uses an 830 nm laser, specifically chosen for pharmaceutical samples as a balance between signal levels, and competing fluorescence of common pharmaceutical excipients.
Calculate your content uniformity ROI
Use our value calculator to see for yourself how much and how soon you could save compared to your current workflows.
The typical example, where 3 batches are analyzed per day, delivers ~$450K of savings in less than 3 years. TRS100 benefits from no sample preparation, no solvents, lower cost of analysis, and lower cost of ownership. Higher volume products and more laborious workflows pay back even faster!
Environmental impact
The TRS100 has been independently audited for its environmental impact and has received the ACT (Accountability, Consistency, Transparency) label, published by My Green Lab.  See how you can reduce your lab’s environmental impact with sustainability-driven innovation.

Question 4

Applications

Accepted Answer

Content uniformity testing
The TRS100 is used for assay and content uniformity (CU) analysis. This fast, non-destructive technique, requiring no sample preparation, can generate a quantitative CU result in less than 15 minutes.
The TRS100 has been approved by regulators and is used to create cost-effective analytical workflows. Watch our customer webinars and learn how pharmaceutical companies are streamlining their QC analytical workflows.
Polymorphs
The TRS100 can be used for polymorph and crystallinity analysis of powders and whole intact tablets for both qualitative and quantitative analysis. The TRS100 can detect residual crystallinity with a limit of detection (LOD) of 0.1-1% w/w.
The ability to ‘see’ inside your pharmaceutical product non-destructively and measure the same sample repeatedly has useful applications in formulation development and stability studies.
Sample versatility
The TRS100 can be used to analyze a variety of sample types including—tablets, hard and soft gel capsules, powders, vials, cuvettes, and well plates.
The versatility of sample presentation options enables a breadth of potential applications, which can all benefit from bulk high-throughput screening.

Question 5

Technology

Accepted Answer

Transmission Raman Spectroscopy (TRS)
Transmission Raman Spectroscopy (TRS) is an ideal method for quantitative analysis of mixtures such as tablets capsules, powders, liquids and suspensions.

Popular Keywords

Categories

Popular Keywords

Categories

TRS100 Quantitative Pharmaceutical Analysis System

TRS100 Quantitative Pharmaceutical Analysis System

Product Details

Transmission Raman

Non-destructive bulk analysis

Calculate your content uniformity ROI

Environmental impact

Content uniformity testing

Polymorphs

Sample versatility

Transmission Raman Spectroscopy (TRS)

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Calibration Standards	NIST SRM706a polystyrene NIST SRM2246 green glass Calibration tray with mercury argon light source
Compliance	21 CFR Part 11 USP <858> USP<1858> EP <2.2.48>
Laser Power	650 mW
Laser Wavelength(s)	830 nm
Resolution	< 8 cm^-1 (FWHM)
Sample Tray Types (Optional)	Tablets Capsules Powders Vials Well plates
Spectral Range	50 to 2,300 cm^-1