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8900 Triple Quadrupole ICP-MS

8900 Triple Quadrupole ICP-MS

The Agilent 8900 triple quadrupole ICP-MS (ICP-QQQ) is the world’s most successful and widely used tandem ICP mass spectrometer. Available in a range of configurations to cover applications from routine contract analysis to advanced research and high-purity materials analysis, the Agilent 8900 ICP-QQQ redefines ICP-MS performance, delivering results you can trust.

The 8900 offers the same matrix tolerance and robustness as Agilent’s market-leading single quadrupole ICP-MS systems, combined with the industry’s most effective helium (He) collision mode. But the 8900 adds tandem mass spec operation (ICP-MS/MS) for unmatched control of reaction chemistry in the collision reaction cell (CRC), making it the world’s most powerful and flexible multi-element analyzer. Let the 8900 ICP-QQQ take control of your interferences and put your results beyond doubt.

8900 Triple Quadrupole ICP-MS

8900 Triple Quadrupole ICP-MS

Product Details

Features
  • MS/MS controls the reaction chemistry ensuring consistent, reliable results, even for previously difficult elements like Si, P, and S
  • Reaction chemistry resolves isobaric overlaps, which are beyond the capability of high-resolution ICP-MS
  • Four-channel cell gas control provides fast, flexible, multi-mode operation
  • A suite of pre-set methods simplifies method setup for routine analysis
  • Helium mode provides simple, effective control of common polyatomic interferences
  • Robust (low CeO/Ce) plasma for unmatched matrix tolerance
  • Ultra High Matrix Introduction (UHMI) technology tolerates samples with up to 25% total dissolved solids (TDS)
  • High sensitivity and low background provide the lowest detection limits for ultratrace analytes
  • Versatility and high performance combine to support advanced research and demanding applications
  • Flexible modes of operation (precursor/product ion scan) support research into reaction chemistry modes
How It Works

What is triple quadrupole ICP-MS (ICP-QQQ)?

Triple quadrupole ICP-MS is a type of tandem mass spectrometer (MS/MS) used for elemental analysis. ICP-QQQ uses an additional quadrupole mass filter (Q1) before the collision/reaction cell (CRC), so spectral interferences can be resolved using reactive cell gases as well as helium (He) collision mode. To give high ion transmission at unit (1 u) mass resolution, both quadrupoles of an ICP-QQQ must be operated under high vacuum. ICP-MS/MS is most beneficial for advanced applications that cannot be run successfully on single quadrupole ICP-MS.

How does triple quadrupole ICP-MS (ICP-QQQ) work?

ICP-QQQ works by filtering the ions twice using two quadrupole mass filters – Q1 before the CRC and Q2 after the CRC. The double mass filtering (MS/MS) controls the reaction processes used to resolve spectral overlaps in the CRC. Q1 rejects all masses except the target analyte, so only the analyte ions and interferences at the same mass can enter the CRC. A reaction gas separates the analyte ions from the overlapping ions without the risk of new product ion overlaps being formed from other elements or isotopes, as can happen with single quadrupole ICP-MS.

What is triple quadrupole ICP-MS (ICP-QQQ) used for?

ICP-QQQ is used for demanding applications that cannot be run well enough using single quadrupole ICP-MS. These applications may require extremely low detection limits, for example measuring ultratrace contaminants in semiconductor process chemicals and high purity materials or detecting the smallest nanoparticles. ICP-QQQ can use MS/MS to resolve isobaric, doubly charged, and adjacent mass overlaps as well as intense polyatomic interferences. This capability allows low level analysis of unusual analytes such as Si, P, S, Cl, and even F.

Applications

Highest sensitivity and MS/MS for unmatched control of interferences in semicon

The semiconductor and materials industries have embraced the lower detection limits and better control of interferences provided by ICP-MS/MS. Leading manufacturers use the 8900 to ensure the quality of their highest purity process chemicals and materials.

Ultrahigh sensitivity, ultralow background, and short, 0.1 ms dwell times ensure the smallest nanoparticles (NPs) are detected accurately. MS/MS controls interferences on Si and Ti, enabling lower level analysis of SiO2 and TiO2 NPs.

Reaction gas modes resolve isobaric overlaps in geochronology and nuclear chemistry

MS/MS controls reaction chemistry in the collision/reaction cell, enabling researchers to separate isobaric overlaps that hinder measurements in geochemistry. The 8900 resolves overlaps such as 204Hg on 204Pb, 87Rb on 87Sr, and 176Lu on 176Hf, allowing accurate isotope ratio analysis for geochronology.
MS/MS also resolves direct overlaps on the radionuclides measured for nuclear research and decommissioning, and improves abundance sensitivity to resolve peak tail overlaps such as 238U on 237Np.

Performance and flexibility to address novel applications in life science

Life science research has been revolutionized by Agilent ICP-QQQ instruments, as ICP-MS/MS resolves spectral overlaps on previously difficult elements such as Cl, P and S. This has enabled researchers, for the first time, to perform direct, compound-independent, quantitative analysis of proteins and peptides, based on the S and P heteroelements.

The ability to perform these novel measurements has opened up new research in fields such as pharmaceutical development, clinical research, and venomics.

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