Q: Technology

Instrument intelligence for non-stop productivity with powerful LC/TQ systems Agilent triple quadrupole LC/MS instruments (LC/TQ), designed to provide rugged and robust analysis, have now been augmented with enhanced instrument intelligence to maximize sample throughput, keep your analysis within tolerance, and prevent unexpected maintenance events. Obtain peace of mind with the Agilent 6475 LC/TQ with MassHunter 12 software for non-stop productivity.

Q: How It Works

End-to-end intelligence capabilities enhance productivity and maximize uptime Onboard intelligence on the 6475 LC/MS system enhances productivity and ensures instrument uptime. Peak performance starts with SWARM autotune to find the best parameters in multidimensional space. Tuning can also be scheduled to ensure peak performance at the start of the day. Early maintenance feedback reports on instrument health so you can quickly troubleshoot or anticipate maintenance. And lastly, intelligent secondary workflows ensure that samples are within tolerance limits, not contaminated, or help quickly screen through samples. Assessing Instrument Sensitivity with Statistical Confidence – IDL With advanced signal processing, the traditional “sensitivity” metric of signal-to-noise (S/N) can be misrepresentative of an instrument’s capability. Instead, replicate injections provide statistics of the instrument’s ability to reliably detect trace analytes. A sensitivity metric using these statistics is called Instrument Detection Limit (IDL). IDL has been rigorously vetted and adopted by the world’s best regulatory agencies and global experts in mass spectrometry. Learn about the origins of IDL and how to apply it to your measurements today.

Q: Applications

Testing for the forever compounds Perfluoro- and polyfluoro-alkyl substances (PFAS/PFOA) are known for their ubiquity in the environment due to their widespread use for a variety of household, commercial, and industrial applications. PFOA and PFAS testing requires a robust and reliable LC/MS/MS to produce sensitive, yet reproducible analysis results. A variety of items such as the PFAS MRM Database or regulation-specific application notes were made for Agilent triple quadrupole LC/MS and will help you stay up to date with regulatory requirements. Robust Pharmaceutical Impurity Testing Nitrosamines are a group of genotoxic pharmaceutical impurities whose effects can be detrimental to human health. As a result, regulatory agencies have set strict guidelines for the presence of nitrosamines in pharmaceuticals. To support the analysis of impurities, Agilent has released one of the first triple quadrupole LC/MS analysis methods for the routine analysis of Nitrosamines. Agilent helps you meet challenging manufacturing and QC demands. Learn more about analytical methods for Nitrosamines and other mutagenic impurities at Agilent Tools for Mutagenic Impurities Analysis.

Question 1

Features

Accepted Answer

Multiple versatile and easy-to-configure ion sources including AJS, ESI, APCI, and MMI allow you to tackle any type of LC/MS analysis
Wide mass range allows the analysis of ions of various classes and sizes, from small molecules to multiply charged peptides
VacShield allows you to do front-end ion injector maintenance without breaking vacuum, drastically reducing routine maintenance from at least 6 hours to 30 minutes
Early maintenance feedback (EMF) provides instrument health and status reports by reporting actively monitored metrics so you can anticipate downtime or address an immediate issue
Intelligent reflex ensures that results are within operational limits through active monitoring of sample carryover and samples above calibration range, adding additional blanks or reducing sample volume if one of these conditions is met
Fast screening workflow with intelligent reflex dramatically improves sample throughput with a shortened LC method for screening and a standard method for quantitation; if a target is detected during screening, the sample is reinjected using a standard quantitation method.
Built-in technical controls combined with procedural controls ensure the security of your data, control access, and facilitate compliance as defined by US FDA 21 CFR Part 11, EU Annex 11, and similar national electronic record regulation

Question 2

Specifications

Accepted Answer

Collision Cell Clearance Time

<1 ms

Dimensions (WxDxH)

47.5 cm x 77.3 cm x 84 cm

IDL Sensitivity (negative)

< 4 fg Chloramphenicol, <4 ppt
IDL spec only for new LC/MS systems using Agilent Jet Stream + checkout column + 1290 Infinity II LC

IDL Sensitivity (positive)

< 3.5 fg Reserpine on-column, < 3.5 ppt
IDL spec only for new LC/MS systems using Agilent Jet Stream + checkout column + 1290 Infinity II LC

Instrument Health Tracking

Early Maintenance Feedback System

Ion Source

ESI
AJS
APCI
MultiMode (ESI+APCI)
NanoESI

MRM Speed

500 MRM transitions/s

Mass Range

m/z 5-3000

Minimum MRM Dwell Time

0.5 ms

Polarity Switch Speed

<25 ms

Quad Resolution (FWHM)

Unit = 0.7 Da
Wide = 1.2 Da
Widest = 2.5 Da
Narrow – 0.4 Da (m/z 5 to 1,500)

Scan Speed

18700 Da/s

Question 3

Technology

Accepted Answer

Instrument intelligence for non-stop productivity with powerful LC/TQ systems
Agilent triple quadrupole LC/MS instruments (LC/TQ), designed to provide rugged and robust analysis, have now been augmented with enhanced instrument intelligence to maximize sample throughput, keep your analysis within tolerance, and prevent unexpected maintenance events. Obtain peace of mind with the Agilent 6475 LC/TQ with MassHunter 12 software for non-stop productivity.

Question 4

How It Works

Accepted Answer

End-to-end intelligence capabilities enhance productivity and maximize uptime
Onboard intelligence on the 6475 LC/MS system enhances productivity and ensures instrument uptime. Peak performance starts with SWARM autotune to find the best parameters in multidimensional space. Tuning can also be scheduled to ensure peak performance at the start of the day. Early maintenance feedback reports on instrument health so you can quickly troubleshoot or anticipate maintenance. And lastly, intelligent secondary workflows ensure that samples are within tolerance limits, not contaminated, or help quickly screen through samples.
Assessing Instrument Sensitivity with Statistical Confidence – IDL
With advanced signal processing, the traditional “sensitivity” metric of signal-to-noise (S/N) can be misrepresentative of an instrument’s capability. Instead, replicate injections provide statistics of the instrument’s ability to reliably detect trace analytes. A sensitivity metric using these statistics is called Instrument Detection Limit (IDL).
IDL has been rigorously vetted and adopted by the world’s best regulatory agencies and global experts in mass spectrometry. Learn about the origins of IDL and how to apply it to your measurements today.

Question 5

Applications

Accepted Answer

Testing for the forever compounds
Perfluoro- and polyfluoro-alkyl substances (PFAS/PFOA) are known for their ubiquity in the environment due to their widespread use for a variety of household, commercial, and industrial applications. PFOA and PFAS testing requires a robust and reliable LC/MS/MS to produce sensitive, yet reproducible analysis results. A variety of items such as the PFAS MRM Database or regulation-specific application notes were made for Agilent triple quadrupole LC/MS and will help you stay up to date with regulatory requirements.
Robust Pharmaceutical Impurity Testing
Nitrosamines are a group of genotoxic pharmaceutical impurities whose effects can be detrimental to human health. As a result, regulatory agencies have set strict guidelines for the presence of nitrosamines in pharmaceuticals. To support the analysis of impurities, Agilent has released one of the first triple quadrupole LC/MS analysis methods for the routine analysis of Nitrosamines. Agilent helps you meet challenging manufacturing and QC demands.
Learn more about analytical methods for Nitrosamines and other mutagenic impurities at Agilent Tools for Mutagenic Impurities Analysis.

Popular Keywords

Categories

Popular Keywords

Categories

6475 Triple Quadrupole LC/MS

6475 Triple Quadrupole LC/MS

Product Details

Instrument intelligence for non-stop productivity with powerful LC/TQ systems

End-to-end intelligence capabilities enhance productivity and maximize uptime

Assessing Instrument Sensitivity with Statistical Confidence – IDL

Testing for the forever compounds

Robust Pharmaceutical Impurity Testing

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